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Related Concept Videos

Proteomics01:33

Proteomics

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A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
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Extraction: Advanced Methods00:56

Extraction: Advanced Methods

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Metal ions can be separated from one another by complexation with organic ligands–the chelating agent– to form uncharged chelates. Here, the chelating agent must contain hydrophobic groups and behave as a weak acid, losing a proton to bind with the metal. Since most organic ligands used in this process are insoluble or undergo oxidation in the aqueous phase, the chelating agent is initially added to the organic phase and extracted into the aqueous phase. The metal-ligand complex is...
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Overview of Advanced Functional Groups02:22

Overview of Advanced Functional Groups

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Functional groups are groups of atoms with specific chemical properties that occur within organic molecules and are sometimes denoted as “R”. Functional groups can “functionalize” a compound by enabling it to adopt different physical and chemical properties.
Types of Advanced Functional Groups
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Sample Preparation for Analysis: Advanced Techniques01:08

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Accurate analysis of complex samples often requires advanced preparation techniques to achieve reliable and reproducible results. Samples containing inorganic or organic materials can be challenging to dissolve or decompose effectively. Standard sample preparation methods include acid digestion, fusion, dry ashing, and wet digestion.
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Cardiopulmonary Resuscitation V: Advanced Airway Management Techniques01:30

Cardiopulmonary Resuscitation V: Advanced Airway Management Techniques

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Airway management is essential in emergency and surgical medicine, ensuring ventilation and oxygenation in patients who cannot maintain their own airway. Clinicians use a range of techniques and devices to secure the airway, depending on the patient’s condition and the clinical context. Key methods include endotracheal intubation, rapid sequence intubation (RSI), supraglottic airway devices, and advanced visualization aids. In cases where these approaches fail, surgical airway...
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Surveys02:16

Surveys

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Often, psychologists develop surveys as a means of gathering data. Surveys are lists of questions to be answered by research participants, and can be delivered as paper-and-pencil questionnaires, administered electronically, or conducted verbally. Generally, the survey itself can be completed in a short time, and the ease of administering a survey makes it easy to collect data from a large number of people.
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Related Experiment Video

Updated: Jan 26, 2026

Proteomic Sample Preparation from Formalin Fixed and Paraffin Embedded Tissue
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Proteomic Sample Preparation from Formalin Fixed and Paraffin Embedded Tissue

Published on: September 2, 2013

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Recent technical advances in proteomics.

John R Yates1

  • 1Molecular Medicine and Neurobiology, Scripps Research, 0550 North Torrey Pines Road, SR302, La Jolla, CA, 92037, USA.

F1000Research
|April 19, 2019
PubMed
Summary
This summary is machine-generated.

Mass spectrometry advancements enhance proteomic discovery capabilities. New methods leverage these improved proteomic tools for capturing vital biological insights.

Keywords:
interaction proteomicsmass spectrometryproteomicsspatial proteomics

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Related Experiment Videos

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Area of Science:

  • Proteomics
  • Analytical Chemistry
  • Biotechnology

Background:

  • Mass spectrometry is a foundational technology in proteomics.
  • Recent technical progress in mass spectrometry has significantly boosted discovery potential.
  • Development of novel methods complements these proteomic advancements.

Purpose of the Study:

  • To highlight the impact of mass spectrometry innovations on proteomics.
  • To discuss the integration of new biological information capture methods with advanced proteomic tools.

Main Methods:

  • Review of recent technical advances in mass spectrometry.
  • Analysis of newly developed methods for biological information capture.

Main Results:

  • Significant improvements in proteomic discovery capabilities due to mass spectrometry.
  • Enhanced capacity for capturing biological information through integrated approaches.

Conclusions:

  • Technological progress in mass spectrometry is a key driver in proteomics.
  • Synergistic development of methods and instrumentation expands biological understanding.