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Related Experiment Video

Updated: Jan 26, 2026

Evaluating the Function of the Foot Core System in the Elderly
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[Glioblastoma in the elderly].

Florence Laigle-Donadey1

  • 1Service de neurologie Mazarin, Hôpital Pitié-Salpêtrière, Paris, France.

Geriatrie Et Psychologie Neuropsychiatrie Du Vieillissement
|April 19, 2019
PubMed
Summary

Malignant glioma treatment in elderly patients is shifting towards active strategies. Radiotherapy with temozolomide chemotherapy benefits older adults with good status, while chemotherapy alone may help those with poor status.

Area of Science:

  • Neuro-oncology
  • Geriatric Medicine
  • Clinical Oncology

Background:

  • Malignant gliomas incidence is rising in the elderly.
  • Increasing age is a significant negative prognostic factor for gliomas.
  • Traditional nihilistic approaches are evolving towards active management.

Purpose of the Study:

  • To review current and evolving treatment strategies for malignant gliomas in the elderly.
  • To highlight the efficacy of specific treatment modalities in this demographic.
  • To emphasize the need for tailored therapeutic approaches and further research.

Main Methods:

  • Review of prospective randomized studies and clinical trial data.
  • Analysis of treatment outcomes based on patient functional status.
Keywords:
chemotherapyclinical trialselderlygliomasincidencequality of liferadiotherapy

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  • Consideration of patient-reported outcomes and comorbidities.

    • Main Results:

    • Radiotherapy plus temozolomide chemotherapy shows benefit in older patients with good functional status.
    • Chemotherapy alone can be effective for elderly patients with poor functional status.
    • Symptomatic treatments like corticosteroids and antiepileptics may be less tolerated and require careful use.

    Conclusions:

    • Treatment decisions for elderly glioma patients must consider performance status, quality of life, comorbidities, and patient/caregiver wishes.
    • Active treatment strategies, including combined chemo-radiotherapy and chemotherapy, are increasingly viable.
    • Further prospective randomized trials are essential to optimize treatment protocols for malignant glioma in the elderly population.