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A noncoding RNA LINC00504 interacts with c-Myc to regulate tumor metabolism in colon cancer

Jinfeng Feng1, Jun Ma1, Shaoqun Liu1

  • 1Department of General Surgery, Minhang Hospital, Fudan University, Shanghai, China.

Journal of Cellular Biochemistry
|April 19, 2019
PubMed

Insights

Long non-coding RNA LINC00504 promotes colon cancer growth by regulating metabolism. It interacts with c-Myc, suggesting LINC00504 as a potential therapeutic target for colon cancer.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Long non-coding RNAs (lncRNAs) play roles in tumor progression.
  • The function and mechanism of LINC00504 in colon cancer are largely unknown.

Purpose of the Study:

  • To investigate the role of LINC00504 in colon cancer.
  • To elucidate the underlying mechanisms of LINC00504 action.

Main Methods:

  • lncRNA profiling to identify LINC00504.
  • In vitro assays (viability, migration) and in vivo xenograft models.
  • Mechanistic studies involving c-Myc interaction and transcriptional regulation.

Main Results:

  • LINC00504 is upregulated in colon cancer tissues and cell lines.
  • LINC00504 enhances colon cancer cell viability, migration, and tumor growth.
  • LINC00504 regulates metabolic pathways by interacting with c-Myc and enhancing its activity.

Conclusions:

  • LINC00504 acts as an oncogenic lncRNA in colon cancer.
  • LINC00504 reprograms cancer cell metabolism via c-Myc.
  • LINC00504 represents a potential therapeutic target for colon cancer treatment.
Keywords:
LINC00504c-Myccolon cancerlncRNAmetabolism

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