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Updated: Jan 26, 2026

Electroactive Polymer Nanoparticles Exhibiting Photothermal Properties
Published on: January 8, 2016
Triplet Tellurophene-Based Semiconducting Polymer Nanoparticles for Near-Infrared-Mediated Cancer Theranostics
Kaikai Wen1, Xiaozhou Xu1, Jun Chen2
1College of Materials Science and Opto-Electronic Technology & Center of Materials Science and Optoelectronics Engineering & CAS Center for Excellence in Topological Quantum Computation & CAS Key Laboratory of Vacuum Physic , University of Chinese Academy of Sciences , Beijing 100049 , P. R. China.
Abstract:
Semiconducting polymer (SP) nanoparticles (NPs) have recently emerged as one of the most promising agents for photoacoustic imaging (PAI)-guided photothermal/photodynamic therapy (PTT/PDT). Herein, a triplet tellurophene-based SP (PNDI-2T) was synthesized with efficient tin-free direct heteroarylation polycondensation. The PNDI-2T NPs display remarkable near-infrared absorption and low cytotoxicity. In addition, PNDI-2T NPs can generate abundant reactive oxygen species (ROS) since tellurophene facilitates the intersystem crossing to generate triplet excited states. Remarkably, PNDI-2T NPs present a high photothermal conversion efficiency (η = 45%) and a high ROS yield (ΦΔ = 38.7%) under 808 nm laser irradiation. Furthermore, we showed that PNDI-2T NPs could be excellent PAI-guided PTT/PDT agents for cancer theranostics. This study provides a new route to developing highly efficient and low cytotoxic agents for PAI-guided PTT/PDT.
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