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Updated: Jan 26, 2026

In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
Effect of Text Messaging on Risk Factor Management in Patients With Coronary Heart Disease: The CHAT Randomized
Xin Zheng1, Erica S Spatz2, Xueke Bai1
1National Clinical Research Center of Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (X.Z., X.B., X.H., X.W., W.G., X.Y., Y.S., X.W., H.Z., J. Liu, J. Li., X.L.).
Mobile health text messages did not significantly lower blood pressure in Chinese coronary heart disease patients. However, the intervention was feasible and well-received, showing potential for patient engagement in secondary prevention.
Area of Science:
- Cardiology
- Digital Health
- Public Health
Background:
- Mobile health (mHealth) offers scalable, low-cost interventions for patient engagement and behavior change.
- Coronary heart disease (CHD) management requires effective secondary prevention strategies.
- Culturally sensitive interventions are crucial for diverse patient populations.
Purpose of the Study:
- To evaluate a culturally sensitive mHealth text messaging intervention for secondary prevention in Chinese patients with CHD.
- To determine if the intervention improves control of cardiovascular risk factors.
Main Methods:
- A multicenter, single-blinded randomized controlled trial involving 822 CHD patients in China.
- Intervention group received 6 weekly text messages for 6 months; control group received 2 monthly messages.
- Primary endpoint: change in systolic blood pressure; secondary endpoints: LDL-C, BMI, physical activity, smoking status.
Main Results:
- No significant difference in systolic blood pressure reduction between groups (mean net change -1.3 mm Hg, P=0.221).
- No significant differences observed in LDL-C, BMI, physical activity, or smoking status.
- High patient acceptability: 96.1% found messages useful, 98.8% easy to understand.
Conclusions:
- Text messaging intervention did not significantly improve blood pressure control in CHD patients at 6 months.
- The mHealth intervention demonstrated feasibility and high patient acceptability.
- Further research may explore optimizing text message content and delivery for secondary prevention.
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