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Author Spotlight: Advancing Syphilis Research — Innovations in Treponema pallidum Cultivation and Genetic Engineering
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[Ocular Syphilis May Lead to Persistent Visual Dysfunction].

Timothy Hamann1, Mayss Al-Sheikh1, Sandrine Zweifel1

  • 1Augenklinik, UniversitätsSpital Zürich, Universität Zürich, Schweiz.

Klinische Monatsblatter Fur Augenheilkunde
|April 19, 2019
PubMed
Summary
This summary is machine-generated.

Ocular syphilis presents with diverse eye conditions, and while antibiotic treatment can control inflammation, many patients experience lasting vision problems. Papillitis and retinitis increase the risk of persistent visual dysfunction despite therapy.

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Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Neurosyphilis

Background:

  • Ocular syphilis is a re-emerging infectious disease with varied clinical presentations.
  • It can affect any part of the eye, leading to significant visual impairment.

Purpose of the Study:

  • To describe the range of intraocular and systemic findings in patients with ocular syphilis.
  • To analyze persistent visual dysfunction and structural abnormalities despite antibiotic treatment.

Main Methods:

  • Retrospective analysis of ocular syphilis patients treated at University Hospital Zurich (2010-2018).
  • Evaluation of general characteristics, ocular manifestations, and visual function (best-corrected visual acuity, visual field) before and after treatment.

Main Results:

  • 17 patients (1 female, 16 male) diagnosed with ocular syphilis; 82% had bilateral involvement.
  • Common manifestations included posterior uveitis, panuveitis, and papillitis. 47% had abnormal cerebrospinal fluid findings; 6 patients were HIV-positive.
  • While intravenous benzyl penicillin inactivated inflammation, 3 patients had persistent visual acuity deficits (BCVA ≤0.6) and 5 had visual field defects. Retinal structural abnormalities correlated with vision loss.

Conclusions:

  • Ocular syphilis displays a wide spectrum of manifestations.
  • Over a third of affected eyes had lasting visual impairment despite appropriate antibiotic therapy.
  • Patients with papillitis and retinitis face a higher risk of persistent visual dysfunction.