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Updated: Jan 26, 2026

In Vivo Multimodal Imaging and Analysis of Mouse Laser-Induced Choroidal Neovascularization Model
Published on: January 21, 2018
Choroidal Neovascularisation Complicating Chronic Central Serous Chorioretinopathy: The Discovery Rate on Multimodal
Khaled Romdhane1, Irmela Mantel1
1Department of Ophthalmology, University of Lausanne, Jules Gonin Eye Hospital, Fondation Asile des Aveugles, Lausanne, Switzerland.
Purpose:
To identify the image modality allowing identification of choroidal neovascularisation (CNV) complicating chronic central serous chorioretinopathy (CSCR), including fluorescein angiography (FA), indocyanine green angiography (ICGA), and optical coherence tomography angiography (OCT-A).
Methods:
Patients diagnosed with chronic CSCR and secondary CNV were included in the study. The image modalities FA, ICGA, and OCT-A were reviewed for specific CNV signs permitting diagnosis. Patients with missing image modalities, poor image quality, previous laser treatment, or other confounding pathologies were excluded.
Results:
CNV was identified on OCT-A in 32 of 33 eyes (97%), whereas ICGA revealed an abnormal vascular network in 23 eyes (70%), significantly less frequently than with OCT-A (p = 0.003). FA allowed CNV identification in 10 eyes (30%), significantly less frequently than with OCT-A (p < 0.001). Type 1 CNV was detected by OCT-A in 29 of 30 eyes (97%), by ICGA in 20 eyes (67%; p = 0.0027), and by FA in 8 eyes (27%; p < 0.001).
Conclusions:
OCTA is a useful diagnostic tool to detect occult CNV complicating chronic CSCR. This image modality might be important for adequate patient care.
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