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Updated: Jan 26, 2026

Postproduction Processing of Electrospun Fibres for Tissue Engineering

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Published on: August 9, 2012

Engineered Electrospun Polyurethane Composite Patch Combined with Bi-functional Components Rendering High Strength

Mohan Prasath Mani¹, Saravana Kumar Jaganathan^2,3,4, Ahmad Athif Mohd Faudzi^5,6

¹School of Biomedical Engineering and Health Sciences, Faculty of Engineering, Universiti Teknologi Malaysia, Skudai 81310, Malaysia. mohanprasathutm@gmail.com.

|April 20, 2019

Summary

This summary is machine-generated.

Researchers developed a novel nanocomposite using electrospun polymers, basil oil, and titanium dioxide (TiO2) nanoparticles. This material shows improved mechanical strength and blood compatibility, making it suitable for cardiovascular applications.

Keywords:

basil/titanium dioxide biocompatibility cardiac tissue applications physico-chemical properties polyurethane

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Area of Science:

Biomaterials Science
Nanotechnology
Cardiovascular Engineering

Background:

Cardiovascular applications demand nanomaterials with superior mechanical and blood compatibility.
Existing materials often face limitations in these properties.

Purpose of the Study:

To develop a novel electrospun nanocomposite for cardiovascular applications.
To enhance mechanical properties and blood compatibility using basil oil and titanium dioxide (TiO2) nanoparticles.

Main Methods:

Electrospinning of a novel nanocomposite incorporating basil oil and TiO2 particles.
Characterization using Fourier transform infrared spectroscopy (FTIR), thermal analysis, and mechanical testing.
Assessment of blood compatibility through coagulation time and red blood cell interaction studies.
Evaluation of cellular toxicity on surrounding tissues.

Main Results:

The nanocomposite exhibited increased hydrophobicity and reduced fiber diameter compared to the pristine polymer.
FTIR confirmed interactions between the polymer and added substances.
Thermal analysis indicated increased onset degradation temperature.
Mechanical testing revealed enhanced tensile strength.
The composite demonstrated delayed coagulation times and safe interaction with red blood cells.
Cellular toxicity was lower than the pristine polymer.

Conclusions:

The developed nanocomposite possesses enhanced physicochemical properties and superior blood compatibility.
The material's improved characteristics suggest its suitability for cardiac tissue engineering and cardiovascular applications.
This novel material offers a promising alternative for advanced biomedical devices in cardiology.