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The role of fecal calprotectin in pediatric disease

Su Jin Jeong1

  • 1Department of Pediatrics, Bundang CHA Medical Center, CHA University School of Medicine, Seongnam, Korea.

Korean Journal of Pediatrics
|April 20, 2019
PubMed

Insights

Fecal calprotectin (FC), an inflammation marker, aids in differentiating inflammatory bowel disease (IBD) from irritable bowel syndrome. This review highlights FC

Area of Science:

  • Gastroenterology
  • Clinical Biomarkers
  • Pediatric Diseases

Background:

  • Fecal calprotectin (FC) is an S100 protein released by neutrophils during inflammation.
  • FC is valuable for distinguishing inflammatory bowel disease (IBD) from irritable bowel syndrome (IBS).

Purpose of the Study:

  • To summarize current literature on fecal calprotectin's clinical applications.
  • To review FC's utility in diagnosing and managing pediatric gastrointestinal diseases.

Main Methods:

  • Literature review of studies on fecal calprotectin.
  • Analysis of FC's role in clinical practice for various gastrointestinal conditions.

Main Results:

  • FC is a useful biomarker for differentiating IBD from IBS.
  • Evidence supports FC's use in diagnosing, monitoring, and evaluating treatment response in pediatric GI diseases like IBD, colitis, and necrotizing enterocolitis.

Conclusions:

  • Fecal calprotectin is a key biomarker in gastroenterology and pediatric gastrointestinal disease management.
  • FC aids clinicians in diagnosis and therapy evaluation for inflammatory and non-inflammatory conditions.

Keywords:
Fecal calprotectinInflammatory bowel diseasePediatric gastrointestinal diseases

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