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Spontaneous behaviors drive multidimensional, brainwide activity.

Carsen Stringer1,2, Marius Pachitariu1,3, Nicholas Steinmetz4

  • 1HHMI Janelia Research Campus, Ashburn, VA 20147, USA. stringerc@janelia.hhmi.org pachitarium@janelia.hhmi.org kenneth.harris@ucl.ac.uk.

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Summary
This summary is machine-generated.

Spontaneous brain activity in the visual cortex encodes complex behavioral states and integrates sensory information. This neural population activity reliably combines external stimuli with internal, multidimensional behavioral data.

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Area of Science:

  • Neuroscience
  • Computational Neuroscience
  • Systems Neuroscience

Background:

  • Neuronal populations in the sensory cortex display variable responses to stimuli and exhibit complex spontaneous activity.
  • The functional role of cortical variability and spontaneous activity is debated, with hypotheses including random noise, memory recall, or encoding of behavioral/cognitive states.

Purpose of the Study:

  • To investigate the nature and function of spontaneous activity in the mouse visual cortex.
  • To determine if spontaneous activity encodes information about the animal's ongoing behavior and sensory inputs.

Main Methods:

  • Recorded activity from over 10,000 neurons in the mouse visual cortex.
  • Analyzed neural population activity during spontaneous and stimulus-evoked conditions.
  • Utilized dimensionality reduction techniques to decode latent behavioral states from neural activity.

Main Results:

  • Spontaneous activity reliably encoded a high-dimensional latent state related to the mouse's ongoing behavior.
  • This behavioral encoding was distributed across the forebrain, not limited to the visual cortex.
  • Sensory inputs were represented in orthogonal dimensions, adding to the ongoing spontaneous activity signal without disrupting it.

Conclusions:

  • Visual cortical population activity, despite its apparent variability, robustly encodes complex behavioral information.
  • Neural activity represents an orthogonal fusion of sensory information and multidimensional behavioral states.
  • Spontaneous neural activity plays a crucial role in representing internal states and integrating them with external sensory data.