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Related Experiment Video

Updated: Jan 26, 2026

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Plasma Vitamin C Concentrations and Cognitive Function: A Cross-Sectional Study.

Nikolaj Travica1,2, Karin Ried2,3,4, Avni Sali2

  • 1Centre for Human Psychopharmacology, Swinburne University of Technology, Melbourne, VIC, Australia.

Frontiers in Aging Neuroscience
|April 20, 2019
PubMed
Summary
This summary is machine-generated.

Higher vitamin C levels are linked to better cognitive function in adults. This study found adequate vitamin C concentrations correlated with improved attention, memory, and processing speed.

Keywords:
ascorbic acidattentioncentral nervous systemcognitiontotal recallvitamin C

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Area of Science:

  • Neuroscience
  • Nutritional Science
  • Human Physiology

Background:

  • Vitamin C is essential for central nervous system (CNS) functions, including neuronal development and myelin formation.
  • Humans cannot synthesize Vitamin C, necessitating dietary intake or supplementation.
  • Previous research highlighted a need to investigate plasma Vitamin C and cognition in healthy adults using direct measurements and sensitive cognitive tests.

Purpose of the Study:

  • To examine the association between plasma Vitamin C concentrations and cognitive performance in cognitively intact adults.
  • To compare cognitive function between participants with adequate versus deficient plasma Vitamin C levels.
  • To validate cognitive assessment tools for measuring age-related cognitive changes.

Main Methods:

  • A cross-sectional study involving 80 healthy adults (aged 24-96).
  • Cognitive assessments included the Swinburne-University-Computerized-Cognitive-Assessment-Battery (SUCCAB), Symbol-Digits-Modalities-Test (SDMT), and Hopkins-Verbal-Learning-Test-Revised (HVLT-R).
  • Plasma Vitamin C levels were biochemically analyzed and participants categorized into adequate (≥28 μmol/L) or deficient (<28 μmol/L) groups.

Main Results:

  • Adequate Vitamin C levels were significantly associated with better performance on choice reaction time, immediate recognition memory, congruent Stroop tasks, and delayed recognition tasks (SUCCAB), after adjusting for age.
  • Participants with adequate Vitamin C showed significantly higher scores in immediate, delayed, and total recall (HVLT-R), and on the SDMT, after adjusting for age or supplementation.
  • No significant difference in cognitive performance was observed between Vitamin C obtained through diet versus supplementation.

Conclusions:

  • Plasma Vitamin C concentration is significantly associated with cognitive functions including attention, working memory, decision speed, and memory recall and recognition.
  • Maintaining adequate plasma Vitamin C levels may support cognitive health in adults.
  • Both dietary intake and supplementation contribute to adequate plasma Vitamin C levels, impacting cognitive performance.