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Aspirin reduced recurrent stroke risk in patients with lacunar stroke

Tao Kong1, Jingzhou Chen1, Kai Sun1

  • 1Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.

Acta Neurologica Scandinavica
|April 20, 2019
PubMed

Insights

Aspirin significantly reduces the risk of recurrent stroke in patients with lacunar stroke. This antiplatelet therapy is crucial for preventing further vascular events in this high-risk population.

Area of Science:

  • Neurology
  • Cardiovascular Medicine
  • Clinical Research

Background:

  • Lacunar stroke carries a poor long-term prognosis with a high risk of recurrence.
  • Existing data on antiplatelet therapy for lacunar infarction are limited.
  • Aspirin is a common preventive measure for ischemic stroke.

Purpose of the Study:

  • To investigate the long-term effect of aspirin on stroke recurrence risk.
  • To evaluate aspirin's impact on vascular events in lacunar stroke patients.

Main Methods:

  • A multicenter prospective cohort study included 544 lacunar stroke patients.
  • Patients were divided into aspirin (n=342) and non-aspirin (n=202) groups.
  • Kaplan-Meier analysis and Cox regression models assessed stroke recurrence.

Main Results:

  • Over a median 4.1-year follow-up, aspirin non-users showed a higher risk of recurrent stroke and vascular events.
  • Aspirin use was associated with a significant reduction in stroke recurrence (HR=0.67, 95% CI 0.45-0.99).
  • Aspirin also reduced the risk of major vascular events and vascular death.

Conclusions:

  • Aspirin significantly reduces stroke recurrence in patients with lacunar stroke.
  • This finding supports the use of aspirin for secondary prevention in lacunar stroke.
  • Long-term aspirin therapy is beneficial for reducing vascular risks.
Abstract

Keywords:
aspirinlacunar strokerecurrent stroke

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