Related Experiment Video
Updated: Jan 26, 2026

Protocol for Biofilm Streamer Formation in a Microfluidic Device with Micro-pillars
Published on: August 20, 2014
Functionalization at Will of Rim-Differentiated Pillar[5]arenes
Paul Demay-Drouhard1,2, Ke Du1, Kushal Samanta1,2
1Institute for Molecular Design and Synthesis, School of Pharmaceutical Science & Technology , Tianjin University , 92 Weijin Road, Nankai District , Tianjin , 300072 , People's Republic of China.
Abstract:
The development of an efficient synthetic route toward rim-differentiated C5-symmetric pillar[5]arenes (P[5]s), whose two rims are decorated with different chemical functionalities, opens up successive transformations of this macrocyclic scaffold. This paper describes a gram-scale synthesis of a C5-symmetric penta-hydroxy P[5] precursor, and a range of highly efficient reactions that allow functionalizing either rim at will via, e.g., sulfur(VI) fluoride exchange (SuFEx) reactions, esterifications, or Suzuki-Miyaura coupling. Afterward, BBr3 demethylation activates another rim for similar functionalizations.
Related Concept Videos
5-Number Summary
In a box plot, the minimum and maximum data values represent the lower and upper whiskers in the graph, and the median is designated as the center of the box in the chart. The first quartile and third...
Functional Groups
Cellular Differentiation
A zygote is a...
Differential Leveling
Implicit Differentiation
Logarithmic Differentiation

