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Expression of Gstt1 in Type 2 Diabetic Retinopathy Patients

Saima Sharif1, Maha Maqsood1, Shagufta Naz1

  • 1Department of Zoology, Lahore College for Women University, Lahore, Pakistan.

Critical Reviews in Eukaryotic Gene Expression
|April 20, 2019
PubMed

Insights

This study found significant differences in glutathione S-transferases class theta 1 (GSTT1) expression in patients with type 2 diabetes and vision-impairing diabetic retinopathy (DR). Understanding GSTT1 may offer insights into diabetes complications.

Area of Science:

  • Biochemistry
  • Ophthalmology
  • Genetics

Background:

  • Type 2 diabetes mellitus (T2DM) is a complex metabolic disorder influenced by genetic and environmental factors.
  • Metabolic defects in diabetes lead to increased free radicals, causing cellular damage and complications like diabetic retinopathy (DR).
  • Diabetic retinopathy (DR) is a leading cause of vision impairment and blindness in diabetic patients.

Purpose of the Study:

  • To investigate the expression levels of glutathione S-transferases class theta 1 (GSTT1) in individuals with type 2 diabetes and DR.
  • To compare GSTT1 expression between DR patients, diabetic patients without DR, and healthy controls.

Main Methods:

  • The study involved comparing GSTT1 gene expression across three groups: patients with type 2 diabetes and DR, patients with type 2 diabetes but without DR, and a control group.
  • Statistical analysis was performed to determine the significance of observed differences in GSTT1 expression.

Main Results:

  • Highly significant differences (P ≤ 0.05) in GSTT1 expression were observed in DR patients compared to both diabetic and control groups.
  • The findings suggest a potential role for GSTT1 in the pathogenesis of diabetic retinopathy.

Conclusions:

  • GSTT1 expression is significantly altered in patients with type 2 diabetes and diabetic retinopathy.
  • Further research into GSTT1 may elucidate its role in the development and progression of DR, potentially leading to new therapeutic targets.

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