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Related Concept Videos

Le Chatelier's Principle: Changing Concentration02:27

Le Chatelier's Principle: Changing Concentration

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A system at equilibrium is in a state of dynamic balance, with forward and reverse reactions taking place at equal rates. If an equilibrium system is subjected to a change in conditions that affects these reaction rates differently (a stress), then the rates are no longer equal and the system is not at equilibrium. The system will subsequently experience a net reaction in the direction of a greater rate (a shift) that will re-establish the equilibrium. This phenomenon is summarized by Le...
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Le Chatelier's Principle: Changing Temperature02:19

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Consistent with the law of mass action, an equilibrium stressed by a change in concentration will shift to re-establish equilibrium without any change in the value of the equilibrium constant, K. When an equilibrium shifts in response to a temperature change, however, it is re-established with a different relative composition that exhibits a different value for the equilibrium constant.
To understand this phenomenon, consider the elementary reaction:
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Framing Effects03:26

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Information is everywhere and its presentation—such as how and when items are presented—can impact our perceptions and decisions surrounding the info. This broad concept umbrellas framing effects—influences that occur due to the way information is framed in its appearance, whether it’s purely the order or the specific wording of a message. Let’s take a look at numerous ways in which two versions of something can objectively say the same thing, yet we respond in...
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Balancing Redox Equations02:58

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Electrochemistry is the science involved in the interconversion of electrical and chemical reactions. Such reactions are called reduction-oxidation, or redox reactions. These important reactions are defined by changes in oxidation states for one or more reactant elements and include a subset of reactions involving the transfer of electrons between reactant species. Electrochemistry as a field has evolved to yield sufficient insights on the fundamental principles of redox chemistry and multiple...
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Compared with pure water, the solubility of an ionic compound is less in aqueous solutions containing a common ion (one also produced by dissolution of the ionic compound). This is an example of a phenomenon known as the common ion effect, which is a consequence of the law of mass action that may be explained using Le Chȃtelier’s principle. Consider the dissolution of silver iodide:
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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Detecting Anastasis In Vivo by CaspaseTracker Biosensor
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Adding Broccoli to the Biosensor Menu.

Matthew G Costales1, Matthew D Disney1

  • 1Department of Chemistry, The Scripps Research Institute, Jupiter, FL 33458, USA.

Cell Chemical Biology
|April 20, 2019
PubMed
Summary
This summary is machine-generated.

Researchers developed novel RNA integrators to measure low-concentration metabolites in live cells. This breakthrough enables detailed studies of cellular metabolite signaling networks.

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Area of Science:

  • Cellular biology
  • Metabolomics
  • Molecular biology

Background:

  • Small-molecule metabolites are crucial regulators of cellular processes.
  • Low metabolite concentrations often hinder the study of their signaling networks.

Purpose of the Study:

  • To introduce a novel method for measuring low-concentration metabolites in live cells.
  • To enable in-depth investigations of metabolite signaling pathways.

Main Methods:

  • Development of RNA "integrators" capable of sensing and reporting metabolite concentrations.
  • Application of these integrators in live-cell imaging and analysis.

Main Results:

  • Demonstrated the ability of RNA integrators to accurately quantify metabolite levels.
  • Facilitated the study of previously challenging metabolite signaling networks.

Conclusions:

  • RNA integrators represent a powerful new tool for metabolomics research.
  • This technology opens avenues for deeper understanding of cellular regulation by metabolites.