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Curing of Concrete

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The hydration of cement takes place within the water-filled capillary pores. However, environmental elements can disrupt this process by evaporating water from the concrete surfaces. Sealed concrete with a water-cement ratio below 0.5 experiences self-desiccation, leading to water loss. The water loss in concrete is mitigated by curing. This technique involves keeping the concrete saturated to maintain the necessary temperature and moisture conditions, to optimally fill the spaces in the cement...

Curing Methods

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Concrete members with a small surface-to-volume ratio are cured by oiling and moistening the forms before casting the concrete member. These forms can be left in place for a prolonged period to prevent moisture loss, and can be wetted if made of a material suitable for wetting. If the forms are removed early, the concrete member is moistened and covered with polythene sheets to maintain moisture. For large horizontal concrete surfaces exposed to dry weather, a temporary covering is suspended...

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Accelerating concrete curing is achieved by applying heat and additional moisture. This process accelerates the hydration of the cement, resulting in an earlier strength gain in the concrete. Steam curing is a method wherein the concrete products are either transported through a chamber on a conveyor belt or encased in plastic, allowing steam at atmospheric pressure to circulate freely around them. This process begins with a phase of moist curing that typically lasts between 3 to 5 hours, after...

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Related Experiment Video

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Automated Radiochemical Synthesis of [18F]3F4AP: A Novel PET Tracer for Imaging Demyelinating Diseases

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Published on: May 29, 2017

Small Molecules with Big Promises for Curing Demyelinating Diseases.

Fangbin Han¹, Ming-Ming Zhou²

¹Bethune Institute of Epigenetic Medicine, The First Hospital, Jilin University, Changchun 130021, China.

Cell Chemical Biology

|April 20, 2019

Summary

New small molecules targeting cholesterol synthesis promote oligodendrocyte formation and myelin regeneration, offering potential treatments for neurological disorders like multiple sclerosis.

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Area of Science:

Neuroscience
Biochemistry
Pharmacology

Background:

Myelin regeneration is crucial for repairing neuronal damage in neurological disorders, including multiple sclerosis.
Oligodendrocytes are responsible for myelinating axons in the central nervous system.

Purpose of the Study:

To identify small molecule inhibitors of cholesterol biosynthesis.
To evaluate the efficacy of these inhibitors in promoting oligodendrocyte differentiation and myelination.

Main Methods:

Screening of small molecules targeting key enzymes in the cholesterol biosynthesis pathway.
In vitro assays to assess oligodendrocyte precursor cell differentiation.
In vivo studies to evaluate remyelination efficacy.

Main Results:

Identification of novel small molecule inhibitors of cholesterol biosynthesis enzymes.
Demonstration that these inhibitors enhance oligodendrocyte differentiation and promote subsequent remyelination.
Potential therapeutic strategy for promoting myelin repair.

Conclusions:

Inhibiting cholesterol biosynthesis can be a viable strategy to enhance myelin regeneration.
The identified small molecules represent promising therapeutic candidates for treating demyelinating diseases.