Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Alkali Metals

Alkali Metals

Group 1 elements are soft and shiny metallic solids. They are malleable, ductile, and good conductors of heat and electricity. The melting points of the alkali metals are unusually low for metals and decrease going down the group, while the density increases going down the group with the exception of potassium (Table 1).
Table 1: Properties of the alkali metals

Bonding in Metals

Bonding in Metals

Metallic bonds are formed between two metal atoms. A simplified model to describe metallic bonding has been developed by Paul Drüde called the “Electron Sea Model”.

Metallic Solids

Metallic Solids

Metallic solids such as crystals of copper, aluminum, and iron are formed by metal atoms. The structure of metallic crystals is often described as a uniform distribution of atomic nuclei within a “sea” of delocalized electrons. The atoms within such a metallic solid are held together by a unique force known as metallic bonding that gives rise to many useful and varied bulk properties.
All metallic solids exhibit high thermal and electrical conductivity, metallic luster, and malleability....

Metal-Ligand Bonds

Metal-Ligand Bonds

The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...

Properties of Transition Metals

Properties of Transition Metals

Transition metals are defined as those elements that have partially filled d orbitals. As shown in Figure 1, the d-block elements in groups 3–12 are transition elements. The f-block elements, also called inner transition metals (the lanthanides and actinides), also meet this criterion because the d orbital is partially occupied before the f orbitals.

Cardiovascular Drugs: Classification based on Therapeutic Indications

Cardiovascular Drugs: Classification based on Therapeutic Indications

Cardiovascular diseases, encompassing a range of conditions, can significantly affect the heart's operations and the overall circulatory system. These conditions impair the heart's ability to pump blood, leading to a deficit in oxygen supply to crucial organs. Anomalies in the heart's electrical system, known as arrhythmias, can cause heartbeats to accelerate or slow down. Usually, heart rates increase during physical activity and decrease while resting or sleeping. However,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

How Forming a Department-Specific Employee Safety Team Impacted Mitigating Risk and Improving the Safety Culture in an Animal Resources Core Facility.

Applied biosafety : journal of the American Biological Safety Association·2026

Same author

Biosafety Guidelines for Viral Vector-Based Gene Therapies: A Resource for Healthcare and Pharmacy Professionals.

Applied biosafety : journal of the American Biological Safety Association·2026

Same author

Correction: Surface nanocrystallization enhances the biomedical performance of additively manufactured stainless steel.

Journal of materials chemistry. B·2026

Same author

Skeletal Editing of Indazoles and Benzisoxazoles.

Chemical record (New York, N.Y.)·2026

Same author

Nutraceutical interventions for neuroprotection: a comprehensive review.

Biochemical pharmacology·2025

Same author

N-glycan remodeling by α-D-mannosidase and β-D-N-acetylhexosaminidase regulates fruit softening, redox balance, and post-harvest pathogen resistance.

The Plant journal : for cell and molecular biology·2025

Search research articles

Related Experiment Video

Updated: Jan 26, 2026

Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay

Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay

Published on: November 10, 2013

Cisplatin: The first metal based anticancer drug.

¹Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur, Uttar Pradesh 208016, India.

Bioorganic Chemistry

|April 20, 2019

Summary

Cisplatin is a widely used chemotherapy drug for solid cancers, but faces challenges with side effects and resistance. Combination therapies and new platinum-based drug developments aim to improve its effectiveness.

Keywords:

Action Mechanism Anticancer Drugs Cisplatin Combination Therapy Drug Resistance Nanocarrier Side Effects

More Related Videos

Assessing Specificity of Anticancer Drugs In Vitro

Assessing Specificity of Anticancer Drugs In Vitro

Published on: March 23, 2016

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation

Published on: January 19, 2019

Related Experiment Videos

Last Updated: Jan 26, 2026

Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay

Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay

Published on: November 10, 2013

Assessing Specificity of Anticancer Drugs In Vitro

Assessing Specificity of Anticancer Drugs In Vitro

Published on: March 23, 2016

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation

Published on: January 19, 2019

Area of Science:

Oncology
Pharmacology
Drug Development

Background:

Cisplatin (diamminedichloridoplatinum(II)) is a cornerstone chemotherapy agent for numerous solid tumors.
Its efficacy stems from inducing DNA damage and apoptosis in cancer cells.
Significant limitations include dose-limiting toxicities and acquired drug resistance.

Purpose of the Study:

To provide a comprehensive overview of cisplatin, encompassing its history, synthesis, and mechanism of action.
To elucidate the mechanisms underlying cisplatin resistance and explore strategies for overcoming it.
To review the evolution of platinum-based drugs, including next-generation nanocarrier conjugates.

Main Methods:

Systematic review of existing literature on cisplatin.
Analysis of cisplatin's molecular mechanisms and resistance pathways.
Description of historical and current platinum-based drug development.

Main Results:

Cisplatin effectively treats various cancers by inducing DNA lesions and apoptosis.
Resistance mechanisms involve reduced drug accumulation, inactivation, and enhanced DNA repair.
Combination therapies show promise in overcoming resistance and minimizing side effects.

Conclusions:

Cisplatin remains a vital chemotherapeutic agent, despite challenges.
Understanding resistance mechanisms is crucial for optimizing treatment strategies.
Advancements in platinum drug design, including nanocarrier conjugates, offer potential for improved therapeutic outcomes.