Related Experiment Video

Updated: Jan 26, 2026

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

12.0K

GAS8 and its naturally occurring antisense RNA as biomarkers in multiple sclerosis

Mona Patoughi1, Soudeh Ghafouri-Fard1, Shahram Arsang-Jang2

  • 1Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Immunobiology
|April 21, 2019
PubMed

Insights

Growth arrest specific 8 (GAS8) and GAS8-AS1 gene expressions are elevated in multiple sclerosis (MS) patients. GAS8-AS1 shows high accuracy for diagnosing MS in males, suggesting its potential as a biomarker.

Area of Science:

  • Genetics
  • Immunology
  • Neurology

Background:

  • The roles of Growth arrest specific 8 (GAS8) and its antisense RNA (GAS8-AS1) in immune-related disorders, particularly multiple sclerosis (MS), are not well understood.
  • Previous studies have examined GAS8 and GAS8-AS1 expression in various tumor tissues.

Purpose of the Study:

  • To investigate the expression levels of GAS8 and GAS8-AS1 in patients with relapsing-remitting multiple sclerosis (RRMS).
  • To explore the potential association of GAS8 and GAS8-AS1 with MS pathogenesis and their utility as diagnostic biomarkers.

Main Methods:

  • Gene expression analysis was performed on samples from 50 RRMS patients and age- and sex-matched healthy controls.
  • Statistical analyses were used to compare gene expression levels between patient and control groups, and to assess correlations with age and diagnostic accuracy.

Main Results:

  • Both GAS8 and GAS8-AS1 showed significantly higher expression in total MS patients compared to controls.
  • GAS8 expression was significantly higher in female MS patients, while GAS8-AS1 was elevated in male MS patients across age groups.
  • GAS8-AS1 transcript levels demonstrated 99.6% accuracy in diagnosing disease status in male subjects and were inversely correlated with age in male participants.

Conclusions:

  • GAS8 and GAS8-AS1 play a significant role in the pathogenesis of multiple sclerosis.
  • GAS8-AS1 holds promise as a diagnostic biomarker for MS, particularly in a subset of male patients.
Keywords:
GAS8GAS8-AS1Multiple sclerosis

More Related Videos

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool11:35

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool

Published on: June 30, 2014

58.7K
A Protocol for the Use of Remotely-Supervised Transcranial Direct Current Stimulation tDCS in Multiple Sclerosis MS08:18

A Protocol for the Use of Remotely-Supervised Transcranial Direct Current Stimulation tDCS in Multiple Sclerosis MS

Published on: December 26, 2015

18.1K

Related Concept Videos

Regulation of Expression Occurs at Multiple Steps02:24

Regulation of Expression Occurs at Multiple Steps

Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
25.8K
Regulation of Expression Occurs at Multiple Steps02:24

Regulation of Expression Occurs at Multiple Steps

3.9K
What is Natural Selection?01:32

What is Natural Selection?

Natural selection is an evolutionary process in which individuals with survival-promoting traits reproduce at higher rates. These favorable traits become more common within a population or species. Naturally selected traits initially arise via random genetic mutations. In order for selection to occur, there must be variation within a population, the trait controlling the variation must be heritable, and there must be an evolutionary advantage for variation in the trait.
126.5K
RNA Stability01:53

RNA Stability

Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
35.7K
RNA Splicing01:32

RNA Splicing

Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
60.5K
Multiple Allele Traits01:49

Multiple Allele Traits

The Concept of Multiple Allelism
38.0K