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Dynamic Adhesion Assay for the Functional Analysis of Anti-adhesion Therapies in Inflammatory Bowel Disease
Published on: September 20, 2018
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Pro- and anti-inflammatory eicosanoids in psoriatic arthritis
Roxana Coras1,2, Arthur Kavanaugh1, Tristan Boyd1
1Department of Medicine, School of Medicine, University of California, San Diego, 9500 Gilman Drive, San Diego, CA, 92093, USA.
Metabolomics : Official Journal of the Metabolomic Society
|April 21, 2019
Summary
Eicosanoid profiling in psoriatic arthritis (PsA) revealed both pro- and anti-inflammatory molecules correlating with disease activity. Understanding these eicosanoid pathways is crucial for PsA management.
Area of Science:
- Lipidomics
- Immunology
- Rheumatology
Background:
- Eicosanoids are key regulators of inflammation, implicated in inflammatory arthritis.
- Imbalances in eicosanoid pathways may contribute to psoriatic arthritis (PsA) pathogenesis.
- Limited methods previously hindered comprehensive eicosanoid analysis.
Purpose of the Study:
- To perform detailed eicosanoid profiling in patients with PsA.
- To evaluate correlations between serum eicosanoid levels and disease activity parameters in PsA.
Main Methods:
- LC-MS was used to quantify 66 eicosanoids in serum from 41 PsA patients.
- Disease activity was assessed using measures like DAS28, CDAI, and BSA.
- Correlations between eicosanoid levels and clinical scores were analyzed.
Main Results:
- Pro-inflammatory eicosanoids (e.g., PGE2) correlated with joint disease scores.
- Anti-inflammatory eicosanoids derived from eicosapentaenoic acid (EPA) correlated with DAS28 and CDAI.
- DHA-derived resolvin D1 was downregulated in patients with high disease activity.
Conclusions:
- Both pro- and anti-inflammatory eicosanoids are associated with joint disease in PsA.
- These findings suggest complex roles for eicosanoids in PsA pathogenesis, potentially involving both harm and benefit.
- Further research is needed to elucidate the specific roles of these eicosanoids in PsA joint inflammation.
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