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An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells
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Clinical features and treatment outcome of elderly multiple myeloma patients with impaired renal function

Jin Chen1, Hui Liu1, Lijuan Li1

  • 1Department of Hematology, Tianjin Medical University General Hospital, Tianjin, China.

Journal of Clinical Laboratory Analysis
|April 21, 2019
PubMed
Abstract

Insights

Elderly multiple myeloma patients with renal impairment face worse outcomes. Bortezomib treatment improved remission rates and overall survival in this high-risk group.

Area of Science:

  • Hematology
  • Nephrology
  • Geriatrics

Background:

  • Renal impairment (RI) is a frequent complication in multiple myeloma (MM).
  • RI in MM patients is linked to increased mortality and poorer survival rates.

Purpose of the Study:

  • To analyze clinical features and outcomes of elderly MM patients with renal impairment.
  • To compare outcomes between MM patients with and without RI, focusing on treatment effects.

Main Methods:

  • Retrospective analysis of 77 MM patients aged over 70.
  • Comparison of clinical characteristics and survival between patients with and without RI.
  • Evaluation of treatment efficacy, particularly bortezomib, on remission and survival.

Main Results:

  • 61% of elderly MM patients had renal impairment.
  • Low hemoglobin, high creatinine, and hypertension were associated with worse outcomes in RI patients.
  • Bortezomib treatment significantly improved complete remission (CR) and overall survival (OS) in elderly MM patients with RI.

Conclusions:

  • Hemoglobin level is a protective factor, while creatinine and hypertension are risk factors in elderly MM patients with RI.
  • Elderly MM patients with RI have worse median overall survival.
  • Bortezomib therapy enhances CR rates and survival for elderly MM patients with renal impairment.
Keywords:
agebortezomibmultiple myelomarenal impairmentsurvival

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