Related Experiment Video
Updated: Jan 26, 2026

Analysis of Complex Molecules and Their Reactions on Surfaces by Means of Cluster-Induced Desorption/Ionization Mass Spectrometry
Published on: March 1, 2020
Boronate affinity Metal-Organic frameworks for highly efficient cis-diol molecules in-situ enrichment and
Zijun Bie1, Ailan Huang2, Yanan Zhang3
1School of Pharmacy, Bengbu Medical University, 2600 Donghai Avenue, Bengbu, 233000, China; Department of Chemistry, Bengbu Medical University, 2600 Donghai Avenue, Bengbu, 233030, China.
Abstract:
Development of novel matrix for surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) is a hot-spot in research frontiers. Herein, we established novel SALDI-MS approach for the analysis of cis-diol small molecules by using boronate affinity metal-organic frameworks (BA-MOFs) as the sorbent for extraction and later as matrix for SALDI. In the meantime, the prepared BA-MOFs exhibited several significant merits, such as excellent selectivity, tolerance to interference and fast binding equilibria. By integrating the advantages of MOFs and the molecular recognition of boronate affinity, a novel platform for simultaneous enrichment and MS detection of cis-diol small molecules was proposed for the first time. There are only two steps in the operation procedure, which greatly simplified the whole experimental workflow. Efficient analysis of cis-diol small molecules in real samples were also well demonstrated. This proposed novel protocol not only gave new insights into the application of functionalized MOFs, but also promoted the development of SALDI- MS.
More Related Videos
09:38Dithranol as a Matrix for Matrix Assisted Laser Desorption/Ionization Imaging on a Fourier Transform Ion Cyclotron Resonance Mass Spectrometer
Published on: November 26, 2013
10:47Whole-body Mass Spectrometry Imaging by Infrared Matrix-assisted Laser Desorption Electrospray Ionization IR-MALDESI
Published on: March 24, 2016
Related Concept Videos
Matrix-Assisted Laser Desorption Ionization (MALDI)
Ionization Energy
Cis-regulatory Sequences
Alkali Metals
Table 1: Properties of the alkali metals
Chemical Ionization (CI) Mass Spectrometry
Atomic Mass