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Theracurmin Ameliorates Cognitive Dysfunctions in 5XFAD Mice by Improving Synaptic Function and Mitigating Oxidative
Jihyun Kim1, Jaehoon Kim1, Zhouchi Huang2
1Departments of Life and Nanopharmaceutical Science, Kyung Hee University, Seoul 02447, Republic of Korea.
Biomolecules & Therapeutics
|April 22, 2019
Summary
Theracurmin, a bioavailable curcumin, improved cognitive function and memory in Alzheimer
Area of Science:
- Neuroscience
- Pharmacology
- Biochemistry
Background:
- Alzheimer's disease (AD) poses a growing global health challenge.
- Developing effective AD treatments with minimal side effects remains difficult.
- Curcumin's therapeutic potential is limited by its low bioavailability.
Purpose of the Study:
- To investigate the efficacy of Theracurmin, a highly bioavailable curcumin formulation, in ameliorating cognitive decline in a mouse model of Alzheimer's disease.
- To explore the underlying mechanisms of Theracurmin's effects, including its impact on oxidative stress and neuroinflammation.
Main Methods:
- 5XFAD transgenic mice, an established AD model, were treated with varying doses of Theracurmin (100, 300, 1,000 mg/kg) for 12 weeks.
- Cognitive function was assessed using the novel object recognition and Barnes maze tests.
- Antioxidant activity was evaluated by measuring superoxide dismutase (SOD), malondialdehyde (MDA), and glutathione (GSH) levels.
- Synaptic protein expression (synaptophysin, PSD-95) and microglial activation marker (Iba-1) were analyzed.
Main Results:
- Theracurmin treatment significantly improved recognition and spatial memory in 5XFAD mice.
- Theracurmin reversed oxidative stress markers, normalizing MDA, SOD, and GSH levels.
- Theracurmin increased synaptic component expression and decreased microglial activation.
Conclusions:
- Theracurmin demonstrates significant potential in ameliorating cognitive deficits associated with Alzheimer's disease.
- Its mechanisms involve enhancing synaptic function and mitigating oxidative stress and neuroinflammation.
- Theracurmin represents a promising therapeutic agent for cognitive dysfunction in AD.
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