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Serum substance P and vasoactive intestinal peptide levels in infants with acute intussusception

Zhen-Chuang Zhu1, Hai-Bin Wang1, Xue-Qiang Yan1

  • 1Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China.

The Journal of International Medical Research
|April 23, 2019
PubMed

Insights

Serum substance P (SP) levels are higher and vasoactive intestinal peptide (VIP) levels are lower in infants with acute intussusception. These levels normalize with treatment, suggesting a role in the condition's development.

Area of Science:

  • Pediatric Gastroenterology
  • Neurogastroenterology
  • Intestinal Physiology

Background:

  • Intussusception is a common cause of intestinal obstruction in infants.
  • Intestinal neurotransmitters like substance P (SP) and vasoactive intestinal peptide (VIP) play roles in gut motility and function.
  • The specific involvement of SP and VIP in the pathogenesis of infant intussusception requires further elucidation.

Purpose of the Study:

  • To investigate the role of intestinal neurotransmitters, specifically vasoactive intestinal peptide (VIP) and substance P (SP), in infants diagnosed with acute intussusception.
  • To compare serum levels of SP and VIP at various time points (pre- and post-operation) between infants with intussusception and a control group.

Main Methods:

  • A comparative study involving 30 infants with acute intussusception (experimental group) and 30 infants with indirect inguinal hernia (control group).
  • Serum samples were collected pre- and post-operation.
  • Enzyme-linked immunosorbent assay (ELISA) was used to quantify serum levels of SP and VIP.
  • Statistical comparison of neurotransmitter levels between the groups and over time.

Main Results:

  • Serum SP levels were significantly elevated in infants with acute intussusception compared to controls.
  • Following treatment and recovery from intussusception, SP levels demonstrated a gradual decrease.
  • Serum VIP levels were significantly reduced in infants with acute intussusception compared to controls.
  • VIP levels showed a gradual increase post-treatment, correlating with recovery.

Conclusions:

  • The findings suggest a potential association between altered serum levels of SP and VIP and the pathogenetic mechanisms underlying acute intussusception in infants.
  • SP and VIP may serve as potential biomarkers for intussusception and its recovery process.
Abstract

Keywords:
Intussusceptionbowelenteric nervous systeminfantinguinal herniasubstance Pvasoactive intestinal peptide

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