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Updated: Jan 26, 2026

Ion-Exchange Membranes for the Fabrication of Reverse Electrodialysis Device
Published on: July 20, 2021
Hybridizing Simulated Moving Bed and Electrodialysis: Product Purification and Eluent Regeneration
Kiara Kochendoerfer1, Pedro Sa Gomes1, Dennis N Rütze2
1BASF SE Carl-Bosch-Strasse 38 67056 Ludwigshafen Germany.
Abstract:
Complex streams in bio-based industries require efficient downstream processing units. Simulated moving-bed (SMB) chromatography is known to improve process efficiency by reducing resin and buffer requirement, but it can be further enhanced by technology hybridization. In the current experiments, an SMB system has been integrated with a bipolar electrodialysis (BPED) system. SMB purified γ-aminobutyric acid (GABA) from a clarified fermentation broth while BPED processed the product-containing eluent stream into recyclable eluent and purified product streams. The continuous operation did not result in any impurity accumulation.
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