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Related Experiment Video

Updated: Jan 26, 2026

Stereotactically-guided Ablation of the Rat Auditory Cortex, and Localization of the Lesion in the Brain
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Lesion Localization of Poststroke Lateropulsion.

Suzanne R Babyar1,2, Anna Smeragliuolo3, Fatimah M Albazron4

  • 1From the Department of Physical Therapy, Hunter College, The City University of New York, NY (S.R.B.).

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|April 23, 2019
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Lateropulsion, or pusher syndrome after stroke, is linked to brain lesions in the inferior parietal lobe. This finding may improve rehabilitation strategies for stroke survivors with this condition.

Keywords:
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Area of Science:

  • Neuroscience
  • Neurology
  • Rehabilitation Medicine

Background:

  • Previous studies on lateropulsion (pusher syndrome) and brain lesions after stroke yielded inconsistent results.
  • Small, unmatched samples limited the ability to pinpoint specific brain regions associated with lateropulsion.

Purpose of the Study:

  • To determine if lateropulsion in stroke patients localizes to specific brain regions.
  • To utilize a case-control design for robust analysis of lesion-symptom relationships.

Main Methods:

  • Matched 50 patients with lateropulsion to 50 without, controlling for age, stroke onset, motor FIM, lesion side, and gender.
  • Employed multivariate lesion symptom mapping with sparse canonical correlations.
  • Assessed lateropulsion using the Burke Lateropulsion Scale.

Main Results:

  • Lesion symptom mapping identified the inferior parietal lobe (Brodmann Areas 2 and 40) as the region most associated with lateropulsion.
  • Patients with lateropulsion had significantly larger lesion volumes.
  • Group-level differences in motor performance and total Functional Independence Measure (FIM) scores were observed despite matching.

Conclusions:

  • Inferior parietal lobe lesion involvement is a key neuroanatomical determinant for developing lateropulsion.
  • Understanding these anatomical underpinnings can enhance stroke rehabilitation.
  • Findings may inform the development of noninvasive neuromodulation techniques for pusher syndrome.