Related Experiment Video
Updated: Jan 26, 2026

Analyzing Gene Expression from Marine Microbial Communities using Environmental Transcriptomics
Published on: February 18, 2009
Marine Spirotetronates: Biosynthetic Edifices That Inspire Drug Discovery
Alexander A Braddock1, Emmanuel A Theodorakis2
1Department of Chemistry & Biochemistry, University of California San Diego, La Jolla, CA 92093-0358, USA. aabraddo@ucsd.edu.
Abstract:
Spirotetronates are actinomyces-derived polyketides that possess complex structures and exhibit potent and unexplored bioactivities. Due to their anticancer and antimicrobial properties, they have potential as drug hits and deserve further study. In particular, abyssomicin C and tetrocarcin A have shown significant promise against antibiotic-resistant S. aureus and tuberculosis, as well as for the treatment of various lymphomas and solid tumors. Improved synthetic routes to these compounds, particularly the class II spirotetronates, are needed to access sufficient quantities for structure optimization and clinical applications.
Related Concept Videos
Drug Discovery: Overview
Amino Acid Biosynthetic Pathways
Mechanism of Breathing I: Inspiration
The respiratory system, an essential network for breathing, comprises the conducting and respiratory zones, each playing a crucial role in the overall process of respiration. Let us explore the detailed mechanism of inspiration, or inhalation, which is the first phase of the respiratory cycle.
Pathway of Air during Inspiration
During inspiration, air enters our body through the nose or mouth and moves through the conducting zone,...
Pharmacokinetics: Drug–Drug Interactions
Bioequivalence of Drugs: Drugs with Multiple Indications
FDA Approved Drugs: Changes to Approved Drugs

