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Updated: Jan 26, 2026
07:51
Refined Murine Model of Idiopathic Pulmonary Fibrosis
Published on: June 17, 2025
964
Current and Future Idiopathic Pulmonary Fibrosis Therapy
Luca Richeldi1, Fabiana Baldi1, Giuliana Pasciuto1
1Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.
The American Journal of the Medical Sciences
|April 24, 2019
Summary
Recent advances offer new therapies for idiopathic pulmonary fibrosis (IPF), with nintedanib and pirfenidone as current mainstays. Future strategies may combine treatments to improve patient outcomes.
Area of Science:
- Pulmonary Medicine
- Fibrotic Interstitial Lung Diseases
- Pharmacotherapy
Background:
- Idiopathic pulmonary fibrosis (IPF) management has seen significant progress.
- Understanding of IPF pathogenesis and clinical trial design has improved.
- Current treatments aim to slow disease progression.
Purpose of the Study:
- To review approved therapies for IPF.
- To discuss emerging therapeutic strategies for IPF.
- To explore future treatment directions for IPF.
Main Methods:
- Literature review of approved IPF treatments.
- Analysis of ongoing clinical trials for novel IPF therapies.
- Synthesis of current and future therapeutic approaches.
Main Results:
- Nintedanib and pirfenidone are the current standard of care for IPF.
- These drugs have demonstrated efficacy in reducing IPF progression in clinical trials.
- Several new therapeutic targets are under investigation.
Conclusions:
- While current therapies slow IPF progression, an ideal treatment is still needed.
- Future IPF treatment may involve combination strategies targeting multiple pathways.
- The goal is to achieve clinical stabilization or improvement in IPF patients.
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