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Updated: Jan 26, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
Direct bone effects of calcimimetics in chronic kidney disease?
Sandro Mazzaferro1, Marzia Pasquali2
1Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy; Ospedale Universitario Policlinico Umberto I, Rome, Italy.
Abstract:
Calcimimetics are widely used in patients on dialysis to treat secondary hyperparathyroidism. Our current view is that bone effects are only indirect through parathyroid hormone suppression. However, because bone cells express the calcium-sensing receptor, direct calcium-sensing receptor-mediated effects are also possible. New experimental data demonstrate direct anabolic bone actions of calcimimetics, independent of parathyroid hormone suppression. Because these effects could be clinically useful, further studies are necessary to confirm the validity of this observation.
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