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Psoriasis Pathogenesis: Keratinocytes Are Back in the Spotlight
Natalie Garzorz-Stark1, Kilian Eyerich1
1Department of Dermatology and Allergy, Technical University of Munich, Biedersteiner Munich, Germany.
The Journal of Investigative Dermatology
|April 24, 2019
Summary
Psoriasis involves T helper 17 cells. Keratinocytes amplify inflammation and are essential for developing the IL-17-mediated psoriatic skin disease in mice.
Area of Science:
- Immunology
- Dermatology
- Cell Biology
Background:
- Psoriasis is an immune-mediated disease.
- T helper 17 (Th17) cells play a central role in psoriasis pathogenesis.
- The triggers and autoantigens initiating Th17 responses in psoriasis are under investigation.
Purpose of the Study:
- To investigate the role of keratinocytes in amplifying inflammation.
- To determine if keratinocytes are essential for the psoriatic phenotype.
- To understand the IL-17-mediated inflammatory process in psoriasis.
Main Methods:
- Studies involved T helper type 17 cell induction.
- Inflammatory cell recruitment into skin was analyzed.
- The contribution of keratinocytes to the psoriatic phenotype was assessed in a mouse model.
Main Results:
- Keratinocytes were found to amplify inflammation in the skin.
- Keratinocytes were identified as essential for a full psoriatic phenotype.
- The study highlights the critical role of keratinocytes in IL-17-mediated disease.
Conclusions:
- Keratinocytes are not merely passive participants but actively contribute to psoriasis.
- Understanding keratinocyte involvement provides new insights into psoriasis pathogenesis.
- Targeting keratinocyte-mediated inflammation could be a therapeutic strategy for psoriasis.
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