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Updated: Jan 26, 2026

Syngeneic Mouse Orthotopic Allografts to Model Pancreatic Cancer
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Mouse-Derived Allografts: A Complementary Model to the KPC Mice on Researching Pancreatic Cancer In Vivo

Jie Li1, Weikun Qian1, Tao Qin1

  • 1Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.

Computational and Structural Biotechnology Journal
|April 24, 2019
PubMed

Keywords:
ADM, Acinar to ductal metaplasia (ADM)CAFs, Cancer-associated fibroblastsEMT, Epithelial-mesenchyme transitionGEMMs, Genetically engineered mouse modelsGemcitabineKC, LSL-KrasG12D/+, Pdx1-CreKPC, LSL-KrasG12D/+, Trp53fl/+, Pdx1-CreMDAs, Mouse-derived allograftsMDAs-OT, Mouse-derived orthotopic allograft tumor modelsMDAs-ST, Mouse-derived subcutaneous allograft tumor modelsMDSCs, Myeloid-derived suppressor cellsMouse-derived allograftsPDAC, Pancreatic ductal adenocarcinomaPDXs, Patient-derived xenograftsPanINs, Pancreatic intraepithelial neoplasiasPancreatic ductal adenocarcinomaTregs, T regulatory cellsTumor tissue fragment

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