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Exfoliation of Egyptian Blue and Han Blue, Two Alkali Earth Copper Silicate-based Pigments
Published on: April 24, 2014
Cancer Cells Treated by Clusters of Copper Oxide Doped Calcium Silicate
Mostafa Mabrouk1, Sayed Hamed Kenawy1, Gehan El-Tabie El-Bassyouni1
1Refractories, Ceramics and Building Materials Department, National Research Centre (NRC), 33 El Behooth St. Dokki-Giza, Egypt.
Abstract:
Different compositions of copper oxide (CuO)-doped calcium silicate clusters were used to treat the cancer cells. The influence of CuO content on the morphology, drug delivering ability, physicochemical properties and cytotoxicity was investigated. The microcrystalline structure revealed the decrement of the size from (20-36 nm) to (5-7 nm) depending on the copper content percentages. Drug delivering ability of doxycycline hyclate (Dox) was down regulated from 58% to 28%in the presence of the CuO. The inclusion of CuO and Dox didn't show any remarkable changes on the physicochemical properties of the CuO-doped calcium silicate nanoparticles. The CuO-doped calcium silicate sample (5 weight %) exhibited great cytotoxicity against the tested cell lines compared to the CuO-free sample. CuO-doped materials displayed significant anticancer effect; this sheds light on its implication in the treatment of cancer.
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