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Detecting recurrent head and neck cancer using electronic nose technology: A feasibility study
Rens M G E van de Goor1,2, Joey C A Hardy1, Michel R A van Hooren1
1Department of Otorhinolaryngology, Head and Neck Surgery, Maastricht University Medical Center, Maastricht, The Netherlands.
Head & Neck
|April 24, 2019
Summary
An electronic nose (e-nose) shows feasibility in detecting head and neck squamous cell carcinoma (HNSCC) recurrence. This noninvasive tool achieved 83% accuracy in identifying HNSCC in follow-up patients.
Area of Science:
- Oncology
- Biotechnology
- Medical Diagnostics
Background:
- Head and neck squamous cell carcinoma (HNSCC) poses significant challenges in post-treatment monitoring.
- Early detection of locoregional recurrence or new primary tumors is crucial for patient outcomes.
Purpose of the Study:
- To evaluate the diagnostic performance of an electronic nose (e-nose) as a noninvasive tool.
- To assess the e-nose's ability to detect recurrent or new HNSCC after curative treatment.
Main Methods:
- Breath samples were collected from 40 patients (20 with HNSCC recurrence, 20 without).
- An electronic nose (Aeonose) analyzed volatile organic compound patterns.
- Artificial neural networking was used for data analysis.
Main Results:
- The e-nose achieved an 83% diagnostic accuracy.
- This accuracy was in differentiating patients with HNSCC recurrence from those without.
Conclusions:
- The study demonstrates the feasibility of using an e-nose for HNSCC detection.
- The e-nose shows potential as a noninvasive diagnostic tool for HNSCC surveillance.
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