Related Experiment Video
Updated: Jan 26, 2026
12:24
Helical Organization of Blood Coagulation Factor VIII on Lipid Nanotubes
Published on: June 3, 2014
12.7K
[Coagulation test features depending on the AB0-blood groups system antigenic composition.]
O A Gusyakova1, F N Gilmiyarova1, V I Kuzmicheva1
1Samara State Medical University, 43099, Samara, Russia.
Klinicheskaia Laboratornaia Diagnostika
|April 24, 2019
Summary
Blood group antigens influence hemostasis. Individuals with blood group 0 (I) exhibit lower coagulation factor activity, increasing bleeding risk, while others show thrombosis susceptibility.
Area of Science:
- Hematology
- Immunology
- Physiology
Background:
- Normal blood flow relies on balanced coagulation and anticoagulation systems.
- The impact of antigenic determinants, like those in the ABO system, on hemostasis remains under-investigated.
Purpose of the Study:
- To evaluate how ABO blood group antigens on erythrocytes and platelets affect hemostatic parameters.
- To investigate the relationship between blood group antigen presence/absence and coagulation function.
Main Methods:
- Coagulation tests, including factor activity and routine assays, were performed on 52 healthy individuals selected from 127 participants.
- Participants underwent general and biochemical blood analyses.
Main Results:
- Blood group 0 (I) individuals showed significantly reduced activity of coagulation factors VIII and VII and prolonged prothrombin time compared to individuals with 'antigenic' blood groups.
- Variations in both intrinsic and extrinsic coagulation pathway indicators were observed based on ABO blood group.
Conclusions:
- Absence of ABO antigens in blood group 0 (I) may predispose individuals to bleeding due to impaired coagulation.
- Presence of ABO antigens in other blood groups might be associated with increased thrombosis risk due to heightened coagulation system activity.
More Related Videos
11:31Antigens Protected Functional Red Blood Cells By The Membrane Grafting Of Compact Hyperbranched Polyglycerols
Published on: January 2, 2013
18.5K
05:36Herbs-Partitioned Moxibustion on the Navel in a Rat Model of Primary Dysmenorrhea with Cold Coagulation and Blood Stasis
Published on: October 4, 2024
1.2K
Related Concept Videos
01:22Composition of Blood
11.7K
The blood in our bodies comprises three major components: blood plasma, formed elements, and the extracellular matrix. Blood plasma is a yellowish fluid that constitutes 55% of the total blood volume. It is primarily made up of water and essential substances such as electrolytes and proteins. Blood plasma serves as a medium for transporting blood cells and also contains nutrients, enzymes, hormones, antibodies, and gases.
Formed elements constitute the remaining 45% of the blood volume. These...
Formed elements constitute the remaining 45% of the blood volume. These...
11.7K
01:24Composition of Blood Plasma
8.1K
Blood plasma is a fluid that contains approximately 92% water and 8% solutes. The solutes include various types of proteins, which constitute about 7% of the total solutes in the plasma. The high-molecular-weight proteins—albumins, globulins, and fibrinogen—are essential to plasma function. Albumins, making up about 60% of the plasma proteins, maintain the osmotic balance within blood vessels by preventing excessive water leakage. Additionally, albumins serve as carrier proteins,...
8.1K
01:06Coagulation
1.3K
Colloidal solids are solid particles suspended in solution. They are usually negatively charged, attracting a compact primary layer of positively charged ions, which attract more counterions to form an electrical double layer. Electrostatic repulsion between the charged double layers prevents the particles from colliding, stabilizing the colloids. These solids are often undesirable because they can contain toxins that are difficult to remove. Coagulation is a technique that helps aggregate and...
1.3K
01:09Coagulation
9.8K
The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
9.8K
03:35Classifying Matter by Composition
90.0K
Matter: Pure Substances and Mixtures
According to its composition, the matter can be classified into two broad categories — pure substances and mixtures.
A pure substance is a form of matter that has a constant composition throughout with uniform properties. For example, any sample of sucrose has the same composition and same physical properties, such as melting point, color, and sweetness, regardless of the source from which it is isolated.
A mixture is composed of two or...
According to its composition, the matter can be classified into two broad categories — pure substances and mixtures.
A pure substance is a form of matter that has a constant composition throughout with uniform properties. For example, any sample of sucrose has the same composition and same physical properties, such as melting point, color, and sweetness, regardless of the source from which it is isolated.
A mixture is composed of two or...
90.0K
01:21Frequency-dependent Selection
23.3K
When the fitness of a trait is influenced by how common it is (i.e., its frequency) relative to different traits within a population, this is referred to as frequency-dependent selection. Frequency-dependent selection may occur between species or within a single species. This type of selection can either be positive—with more common phenotypes having higher fitness—or negative, with rarer phenotypes conferring increased fitness.
23.3K