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Current Status of Molecular Imaging of Infection: A Primer

Ila Sethi1, Yoram S Baum1, Erin E Grady1

  • 11 Department of Radiology & Imaging Sciences, Division of Nuclear Medicine & Molecular Imaging, Emory University Hospital, 1364 Clifton Rd NE, Atlanta, GA 30322.

AJR. American Journal of Roentgenology
|April 24, 2019
PubMed

Insights

Molecular imaging techniques aid in diagnosing various infections like osteomyelitis and diabetic foot infections. Selecting the right imaging modality is crucial for effective infection detection and management.

Area of Science:

  • Medical imaging
  • Nuclear medicine
  • Infectious disease diagnosis

Background:

  • Molecular imaging has advanced significantly for infection detection.
  • Various infectious conditions pose diagnostic challenges.

Purpose of the Study:

  • To review the applications of molecular imaging in diverse infectious processes.
  • To discuss different imaging modalities used in infection diagnosis.

Main Methods:

  • Review of literature on molecular imaging for infections.
  • Discussion of planar, SPECT, SPECT/CT, 18F-FDG PET/CT, and PET/MRI techniques.
  • Coverage of specific infections: osteomyelitis, diabetic foot, periprosthetic, cardiovascular, abdominal, and fever of unknown origin.

Main Results:

  • Molecular imaging is effective across a spectrum of infectious diseases.
  • Different modalities offer varying diagnostic yields for specific infections.
  • 18F-FDG PET/CT and PET/MRI show promise in complex cases.

Conclusions:

  • Molecular imaging of infection is a multifaceted field.
  • Choosing the appropriate imaging modality is key to answering clinical questions effectively.
  • Expertise in available techniques optimizes diagnostic accuracy for infections.
Keywords:
FDGPET/CTPET/MRISPECT/CTabdominal infectioncardiovascular infectiondiabetic footfever of unknown originimplantable device infectionlabeled leukocytesmethylene diphosphonate (MDP)osteomyelitisperiprosthetic infectionvertebral osteomyelitis

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