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Analysis of Oxidative Stress in Zebrafish Embryos
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Crosstalk between Oxidative Stress and Tauopathy
Md Mamunul Haque1, Dhiraj P Murale2, Yun Kyung Kim3,4
1Molecular Recognition Research Center, Korea Institute of Science and Technology (KIST), Seoul 02792, Korea. mamun@chembiol.re.kr.
International Journal of Molecular Sciences
|April 25, 2019
Summary
Reactive oxygen species (ROS) are linked to tauopathy, a brain disease. This review explores how ROS contribute to tau pathology and discusses antioxidants as potential treatments.
Area of Science:
- Neuroscience
- Biochemistry
Background:
- Tauopathy involves pathological tau protein modifications.
- Reactive oxygen species (ROS) are increasingly recognized for their role in tauopathy.
- Oxidative stress (OS) arises from an imbalance between ROS production and antioxidant defenses.
Purpose of the Study:
- To review the chemical nature of ROS.
- To elucidate the specific roles of ROS in tauopathy.
- To explore the connection between OS and tauopathies.
Main Methods:
- Literature review of studies on ROS and tauopathy.
- Analysis of the biochemical mechanisms linking ROS to tau modifications.
- Examination of evidence for ROS upregulation in tauopathy patients.
Main Results:
- ROS directly promote tau modifications.
- Elevated ROS levels are observed in the brains of tauopathy patients.
- Antioxidants show potential as therapeutic agents for tauopathy.
Conclusions:
- There is a significant link between oxidative stress and tauopathies.
- Understanding ROS in tauopathy is crucial for developing effective treatments.
- Further research into ROS and antioxidant therapies is warranted.
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