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Updated: Jan 25, 2026

Impact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of Training
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Impact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of Training

Published on: October 10, 2019

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Cardiac Troponin T and Troponin I in the General Population

Paul Welsh1, David Preiss2, Caroline Hayward3

  • 1Institute of Cardiovascular and Medical Sciences (P.W., S.P., C.W., N.S.), University of Glasgow, United Kingdom.

Circulation
|April 25, 2019
PubMed

Insights

High-sensitivity cardiac troponin I (cTnI) and cardiac troponin T (cTnT) have different associations with cardiovascular disease (CVD) and non-CVD mortality. cTnI is more linked to CVD events, while cTnT predicts non-CVD death, informing assay selection.

Area of Science:

  • Cardiology
  • Genetics
  • Biomarkers

Background:

  • High-sensitivity cardiac troponins (hs-cTn) are increasingly used for population screening of cardiovascular disease (CVD) and heart failure.
  • The equivalence of cardiac troponin T (cTnT) and cardiac troponin I (cTnI) as risk markers in this context is not established.

Purpose of the Study:

  • To compare the associations of cTnT and cTnI with CVD and non-CVD outcomes.
  • To investigate the genetic determinants of cTnT and cTnI levels through a genome-wide association study.

Main Methods:

  • hs-cTnT and hs-cTnI levels were measured in 19,501 individuals from the Generation Scotland Scottish Family Health Study.
  • Cox proportional hazards models were used to assess associations with composite CVD outcomes, CVD death, non-CVD death, and heart failure over a median follow-up of 7.8 years.
  • Genome-wide association studies (GWAS) were performed to identify genetic loci associated with each troponin type.

Main Results:

  • Both cTnI and cTnT were associated with CVD risk. After adjustment for risk factors, cTnI showed a stronger association with CVD outcomes (HR 1.24) than cTnT (HR 1.11).
  • cTnI was specifically linked to myocardial infarction and coronary heart disease, while cTnT was associated with non-CVD mortality (HR 0.77).
  • GWAS identified distinct genetic loci associated with cTnI (5 loci) and cTnT (4 loci).

Conclusions:

  • The genetic underpinnings and prognostic associations of cTnI and cTnT differ significantly.
  • cTnI elevations are more indicative of CVD risk, whereas cTnT elevations are more associated with non-CVD mortality.
  • These findings have implications for selecting appropriate troponin assays for clinical practice and research.
Abstract

Keywords:
cardiovascular diseasesgeneticsrisk factorstroponintroponin T

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