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Updated: Jan 25, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Advance care planning dispositions: the relationship between knowledge and perception.
Anne Cattagni Kleiner1, Brigitte Santos-Eggimann2, Sarah Fustinoni2
1Center for Primary Care and Public Health (Unisanté), University of Lausanne, Route de la Corniche 10, 1010, Lausanne, Switzerland. anne.cattagni@chuv.ch.
Older adults
Area of Science:
- Gerontology
- Public Health
- Bioethics
Background:
- Legal frameworks for advance care planning (ACP) exist in Switzerland but are underutilized by older adults.
- Existing research suggests a positive correlation between awareness of ACP provisions and their utilization.
- This study investigates the relationship between knowledge and perception of ACP dispositions among older Swiss residents.
Purpose of the Study:
- To examine the association between increased knowledge of advance care planning (ACP) dispositions and a more favorable perception of these legal tools.
- To provide insights into factors influencing the uptake of ACP among the elderly population.
Main Methods:
- A cross-sectional study involving 2125 community-dwelling individuals aged 71-80 in Switzerland (Lausanne cohort 65+).
- Data collection via questionnaires assessing knowledge, use, and perception of lasting power of attorney, advance directives, and health care proxy.
- Statistical analysis included bivariable and multivariable regression to determine associations between knowledge and perception, controlling for covariates.
Main Results:
- A significant portion of participants (50%) lacked awareness of legal dispositions for ACP.
- Low filing rates were observed: 14% for advance directives, 11% for health care proxy, and 6% for lasting power of attorney.
- Higher levels of knowledge regarding ACP dispositions were significantly associated with more positive perceptions, even after adjusting for confounding variables.
Conclusions:
- Enhanced knowledge of advance care planning (ACP) dispositions may positively influence older adults' perceptions of these tools.
- Communication strategies should be tailored to individual knowledge levels and address barriers that decrease with greater awareness.
- Further research is needed to elucidate the causal direction of the observed association between knowledge and perception in ACP.
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