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[Value of S100A8 in evaluating the prognosis of children with acute lymphoblastic leukemia]

Mei-Fei Ouyang1, Dan Wang, Ying-Ting Liu

  • 1Department of Pediatrics, Xiangya Hospital, Central South University, Changsha 410008, China. yamahua123@163.com.

Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics
|April 25, 2019
PubMed

Insights

High S100A8 expression is linked to poor prognosis in pediatric acute lymphoblastic leukemia (ALL). This finding suggests S100A8 may serve as a biomarker for personalized ALL treatment strategies.

Area of Science:

  • Pediatric Oncology
  • Molecular Diagnostics
  • Biomarker Discovery

Background:

  • Acute lymphoblastic leukemia (ALL) is the most common childhood cancer.
  • Identifying reliable prognostic markers is crucial for effective treatment strategies in pediatric ALL.
  • S100A8, a calcium-binding protein, has been implicated in various inflammatory and neoplastic processes.

Purpose of the Study:

  • To investigate the association between S100A8 expression levels and treatment outcomes in children diagnosed with ALL.
  • To evaluate the potential of S100A8 as a prognostic biomarker in pediatric ALL.

Main Methods:

  • Retrospective analysis of clinical data from 377 children with ALL treated with the CCLG-2008-ALL regimen.
  • Quantification of serum S100A8 protein and mRNA levels using ELISA and PCR, respectively.
  • Survival analysis utilizing Kaplan-Meier curves and Cox regression modeling.

Main Results:

  • Overall survival rate was 89.1% in the cohort.
  • Lower S100A8 protein and mRNA levels were observed in patients with a good prednisone response.
  • Elevated S100A8 levels correlated with poorer event-free survival and were associated with different risk stratifications.
  • S100A8 overexpression emerged as an independent risk factor for adverse prognosis in pediatric ALL.

Conclusions:

  • High S100A8 expression is associated with unfavorable prognosis in children with ALL.
  • S100A8 shows promise as a novel biomarker for guiding individualized precision therapy in pediatric ALL patients.
Abstract

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