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[Lupus-type anticoagulants and thromboses].

Y Sultan

    Annales De Medecine Interne
    |January 1, 1986
    PubMed
    Summary

    A lupus circulating anticoagulant factor prolongs coagulation tests and is uncorrected by plasma. This common finding in lupus, other conditions, and healthy individuals is linked to thromboembolic events.

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    Area of Science:

    • Hematology
    • Immunology
    • Clinical Pathology

    Context:

    • Lupus circulating anticoagulants are detected through coagulation tests like activated cephalin time and Quick's test.
    • This anticoagulant activity is characterized by its resistance to correction with normal plasma.
    • The abnormality is not linked to deficiencies in specific coagulation factors.

    Purpose:

    • To describe the diagnostic characteristics of lupus circulating anticoagulants.
    • To highlight the prevalence and clinical associations of this hemostatic abnormality.

    Summary:

    • Prolongation of coagulation tests, including activated cephalin time and Quick's test, indicates the presence of a lupus circulating anticoagulant.
    • This factor's presence is confirmed when the prolonged clotting time is not corrected by adding normal plasma.
    • The anticoagulant is not associated with a deficiency in any coagulation factor and is frequently observed in patients with systemic lupus erythematosus, other diseases, and even in healthy individuals.

    Impact:

    • Recognizing lupus anticoagulants is crucial for understanding potential thromboembolic risks.
    • This finding aids in the differential diagnosis of coagulation disorders.
    • Further research is needed to establish a definitive causal link between lupus anticoagulants and thromboembolic complications.

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