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Related Concept Videos

Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

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Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

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Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
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Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

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Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
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Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
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Complementary DNA01:44

Complementary DNA

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Related Experiment Video

Updated: Jan 25, 2026

Author Spotlight: Development and Application of a Canine IBD Gut-on-a-Chip Model for 3D Intestinal Morphogenesis Studies
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Intestinal Organoids as a Novel Complementary Model to Dissect Inflammatory Bowel Disease.

L Schulte1, M Hohwieler1, M Müller1

  • 1Department of Internal Medicine 1, University Medical Centre Ulm, Ulm, Germany.

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Inflammatory bowel diseases (IBD), including Crohn's disease and ulcerative colitis, significantly impact quality of life. Intestinal organoids offer a promising new model to study IBD pathogenesis and develop better treatments.

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Area of Science:

  • Gastroenterology and Immunology
  • Cell Biology and Disease Modeling

Background:

  • Inflammatory bowel diseases (IBD), encompassing Crohn's disease and ulcerative colitis, are chronic conditions with significant morbidity and healthcare costs.
  • Current understanding of IBD pathogenesis is limited, hindering effective treatment development beyond broad anti-inflammatory approaches.
  • Existing experimental models often fail to replicate the natural development of intestinal inflammation and are limited in assessing the intestinal epithelium's role.

Purpose of the Study:

  • To review the current understanding of IBD pathogenesis.
  • To evaluate the limitations of traditional experimental models in IBD research.
  • To highlight the utility and challenges of intestinal organoid models in studying IBD.

Main Methods:

  • Review of existing literature on IBD pathogenesis and experimental models.
  • Analysis of the advantages and disadvantages of intestinal organoid technology for IBD research.
  • Discussion of potential future applications of organoid models in IBD.

Main Results:

  • Traditional models often induce inflammation artificially and struggle to assess the intestinal epithelium.
  • Intestinal organoids provide a more physiologically relevant model for studying IBD.
  • Organoids allow for detailed investigation of the intestinal epithelium's contribution to IBD pathogenesis.

Conclusions:

  • Intestinal organoids represent a significant advancement in modeling IBD, overcoming limitations of previous experimental systems.
  • Organoid technology offers new avenues for deciphering IBD causes and developing targeted therapies.
  • Further research utilizing organoid platforms is crucial for future IBD treatment strategies.