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Salts are ionic compounds composed of cations and anions, either of which may be capable of undergoing an acid or base ionization reaction with water. Aqueous salt solutions, therefore, may be acidic, basic, or neutral, depending on the relative acid-base strengths of the salt’s constituent ions. For example, dissolving the ammonium chloride in water results in its dissociation, as described by the equation:
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Electrochemical Preparation of Poly3,4-Ethylenedioxythiophene Layers on Gold Microelectrodes for Uric Acid-Sensing Applications
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Uric Acid and Its Correlation with Various Metabolic Parameters: A Population-Based Study.

Pradip Mukhopadhyay1, Sujoy Ghosh1, Kaushik Pandit2

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Indian Journal of Endocrinology and Metabolism
|April 25, 2019
PubMed
Summary

Serum uric acid (SUA) is elevated in metabolic syndrome (MetS) compared to healthy individuals. However, SUA levels do not significantly differ between lean MetS and obese MetS participants.

Keywords:
Lean metabolic syndromemetabolic syndromeuric acid

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Area of Science:

  • Endocrinology
  • Metabolic Disorders
  • Clinical Biochemistry

Background:

  • Serum uric acid (SUA) is linked to metabolic disorders, but data on its prevalence and correlations are limited.
  • Investigating SUA's role in metabolic health is crucial for understanding associated conditions.

Purpose of the Study:

  • To determine the prevalence of SUA abnormalities in a rural population.
  • To examine the correlation between SUA levels and various anthropometric and metabolic parameters, including obesity, dyslipidemia, and metabolic syndrome (MetS).

Main Methods:

  • A cross-sectional study involving 405 participants from a rural area.
  • Evaluation of serum uric acid (SUA) levels and their correlation with anthropometric (e.g., BMI, waist circumference) and metabolic parameters (e.g., blood pressure, lipids, glucose, insulin resistance).
  • Metabolic syndrome (MetS) was defined using International Diabetes Federation (IDF) criteria; Lean MetS was defined based on NCEP ATP-III criteria with below-threshold waist circumference.

Main Results:

  • Mean SUA was 4.2 mg/dL; 3.2% had hyperuricemia (>7.0 mg/dL) and 2.0% had hypouricemia.
  • SUA correlated significantly with age, blood pressure, obesity parameters (weight, BMI, waist circumference), insulin resistance (fasting insulin, HOMA-IR), and lipid profile (LDL-C, HDL-C, triglycerides).
  • SUA levels were elevated in MetS compared to healthy individuals, but not significantly different between Lean MetS and Obese MetS groups.

Conclusions:

  • Serum uric acid (SUA) is elevated in individuals with metabolic syndrome (MetS).
  • SUA levels do not significantly differ between Lean MetS and Obese MetS, suggesting SUA's association with MetS is independent of obesity status within the syndrome.