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Updated: Jan 25, 2026

Kinetic Screening of Nuclease Activity using Nucleic Acid Probes
Published on: November 1, 2019
Aminoglycoside Functionalization as a Tool for Targeting Nucleic Acids
Derrick Watkins1, Krishnagopal Maiti1, Dev P Arya2
1Department of Chemistry, Clemson University, Clemson, SC, USA.
Abstract:
Aminoglycoside functionalization as a tool for targeting natural and unnatural nucleic acids holds great promise in their development as diagnostic probes and medicinally relevant compounds. Simple synthetic procedures designed to easily and quickly manipulate amino sugar (neomycin, kanamycin) to more powerful and selective ligands are presented in this chapter. We describe representative procedures for (a) aminoglycoside conjugation and (b) preliminary screening for their nucleic acid binding and selectivity.
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