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Related Experiment Video

Updated: Jan 25, 2026

Kinetic Screening of Nuclease Activity using Nucleic Acid Probes

Kinetic Screening of Nuclease Activity using Nucleic Acid Probes

Published on: November 1, 2019

Aminoglycoside Functionalization as a Tool for Targeting Nucleic Acids.

Derrick Watkins¹, Krishnagopal Maiti¹, Dev P Arya²

¹Department of Chemistry, Clemson University, Clemson, SC, USA.

Methods in Molecular Biology (Clifton, N.J.)

|April 25, 2019

Summary

Aminoglycoside functionalization enables targeting of nucleic acids for diagnostic and medicinal applications. This study presents synthetic methods for creating selective aminoglycoside ligands and screening their binding capabilities.

Keywords:

Aminoglycoside DNA DNA–RNA Kanamycin Neomycin Nucleic acid binding RNA miRNA

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Area of Science:

Medicinal Chemistry
Molecular Biology
Synthetic Chemistry

Background:

Aminoglycosides are crucial in targeting nucleic acids.
Functionalization of aminoglycosides can enhance their utility as diagnostic probes and therapeutic agents.
Developing selective ligands for nucleic acids is an ongoing challenge.

Purpose of the Study:

To present simple synthetic procedures for manipulating aminoglycosides.
To create more powerful and selective aminoglycoside-based ligands.
To screen these modified aminoglycosides for nucleic acid binding and selectivity.

Main Methods:

Aminoglycoside conjugation strategies.
Synthesis of modified amino sugars (neomycin, kanamycin).
Preliminary screening assays for nucleic acid binding affinity and selectivity.

Main Results:

Demonstrated straightforward synthetic routes for aminoglycoside functionalization.
Developed methods for creating potent and selective ligands.
Preliminary data on nucleic acid binding and selectivity of the synthesized compounds.

Conclusions:

Aminoglycoside functionalization is a viable strategy for developing nucleic acid-targeting agents.
The presented synthetic procedures offer a facile approach to novel ligand discovery.
Further development holds promise for diagnostic probes and medicinally relevant compounds.