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Updated: Jan 25, 2026

Synthesis of Single-Crystalline Core-Shell Metal-Organic Frameworks

Synthesis of Single-Crystalline Core-Shell Metal-Organic Frameworks

Published on: February 10, 2023

Core-Shell-Structured Cyclodextrin Metal-Organic Frameworks for Programmable Cargo Release.

Yifu Chen^1,2, Bo Yu^1,2, Shijie Xu^1,2

¹State Key Laboratory of Chemical Engineering, School of Chemical Engineering and Technology , Tianjin University , Weijin Road 92 , Tianjin 300072 , China.

ACS Applied Materials & Interfaces

|April 25, 2019

Summary

This summary is machine-generated.

Core-shell cyclodextrin metal-organic frameworks (CD-MOFs) enable controlled release of single or multiple components. This research lays the groundwork for advanced programmable drug delivery systems.

Keywords:

core−shell structure crystal engineering host−guest chemistry metal−organic frameworks programmable cargo release

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Area of Science:

Materials Science
Nanotechnology
Drug Delivery

Background:

Metal-organic frameworks (MOFs) offer tunable properties for various applications.
Cyclodextrin-based MOFs (CD-MOFs) are emerging as promising platforms for controlled release.
Designing complex release profiles remains a challenge in cargo delivery systems.

Purpose of the Study:

To investigate the cargo release capabilities of core-shell structured CD-MOFs.
To demonstrate the potential for controlled release of single and multiple components.
To establish a foundation for developing programmable cargo release systems.

Main Methods:

Synthesis of core-shell structured CD-MOFs.
Characterization of CD-MOF structure and properties.
In vitro studies to evaluate monocomponent and bicomponent release kinetics.

Main Results:

Core-shell CD-MOFs successfully achieved delayed and bimodal release of a monocomponent.
Ordered release of a bicomponent was successfully demonstrated using these CD-MOFs.
The design allows for precise control over release profiles.

Conclusions:

Simple core-shell CD-MOF designs enable sophisticated cargo release functionalities.
These findings pave the way for advanced, programmable multi-component delivery systems.
CD-MOFs represent a versatile platform for future drug delivery innovations.