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Bioinformatics Resources for the Study of Glycan-Mediated Protein Interactions
Published on: January 20, 2022
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A Bioinformatics View of Glycan⁻Virus Interactions
Philippe Le Mercier1, Julien Mariethoz2,3, Josefina Lascano-Maillard4,5
1Swiss-Prot Group, SIB Swiss Institute of Bioinformatics, 1211 Geneva, Switzerland. philippe.lemercier@sib.swiss.
Viruses
|April 26, 2019
Summary
This study surveys bioinformatics resources for understanding virus-host interactions involving glycans. It highlights current tools and their limitations for viromics research.
Area of Science:
- Bioinformatics
- Virology
- Glycobiology
Background:
- Glycan molecules play a crucial role in virus-host interactions, with growing evidence documented in online databases.
- Bioinformatics tools are essential for analyzing complex molecular interactions in -omics fields, including viromics.
- The increasing momentum of viromics necessitates enhanced bioinformatics support for studying host-virus interactions.
Purpose of the Study:
- To survey existing bioinformatics resources for searching, visualizing, comparing, and predicting host-virus interactions.
- To specifically identify resources that integrate the role of glycans in these interactions.
- To evaluate the strengths and weaknesses of the current bioinformatics landscape for viromics research.
Main Methods:
- Systematic literature review and database mapping of specialized and general-purpose bioinformatics resources.
- Analysis of database functionalities for host-virus interaction data, with a focus on glycan involvement.
- Illustrative examples of database usage and critical assessment of their capabilities.
Main Results:
- A comprehensive map of relevant bioinformatics databases for host-virus-glycan interactions has been compiled.
- The survey identified both strengths and limitations in the current bioinformatics landscape for this research area.
- Potential applications and areas for improvement in bioinformatics support for viromics were discussed.
Conclusions:
- Current bioinformatics resources offer valuable tools for studying glycan-mediated virus-host interactions.
- Further development is needed to fully support the growing field of viromics and understanding viral infections.
- This survey provides a foundation for researchers navigating the bioinformatics landscape for host-virus interaction studies.
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