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Glycocalyx and its Functions01:14

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The glycocalyx is a carbohydrate-rich, fuzzy-appearing layer on the outer surface of the cell membrane. It is highly hydrophilic, because of this it attracts large amounts of water to the cell's surface. This aids the cell's interaction with the watery environment and also helps it to obtain substances dissolved in the water. It is also important for cell identification, self/non-self determination, and embryonic development and is used in cell-to-cell attachments to form tissues.
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Using Unfixed, Frozen Tissues to Study Natural Mucin Distribution
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Microbial Lectin-Targeting Mucus: A Glycobioinformatic Approach.

Frédérique Lisacek1,2,3, Boris Schnider4,5, David Ohayon6

  • 1Swiss Institute of Bioinformatics, Geneva, Switzerland. frederique.lisacek@sib.swiss.

Methods in Molecular Biology (Clifton, N.J.)
|June 11, 2025
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Summary
This summary is machine-generated.

Microbial lectins bind to human mucin glycans due to co-evolution. The UniLectin portal offers databases like UniLectin3D and LectomeXplore to study these interactions and identify microbial lectins.

Keywords:
3D structureAdhesinCarbohydrate recognition domainDatabaseLigand

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Area of Science:

  • Microbiology
  • Glycobiology
  • Bioinformatics

Background:

  • Mucins are key host-pathogen interaction sites.
  • Microbial surface glycans act as receptors for host proteins.
  • Lectins mediate specific binding between microbes and host mucins.

Purpose of the Study:

  • To describe the co-evolutionary specificity of microbial lectins for human mucin epitopes.
  • To introduce UniLectin portal databases for studying microbial-mucin interactions.
  • To illustrate the use of UniLectin3D and LectomeXplore for research.

Main Methods:

  • Database exploration of microbial-mucin interactions.
  • Structural analysis of lectin-glycan recognition using UniLectin3D.
  • Genomic analysis for identifying lectins in mucin-associated microbiomes via LectomeXplore.

Main Results:

  • Specificity of microbial lectins towards mucin epitopes is shaped by co-evolution.
  • UniLectin3D provides detailed structural insights into recognition.
  • LectomeXplore facilitates the discovery of potential lectins in microbial genomes.

Conclusions:

  • The UniLectin portal is a valuable resource for understanding host-microbe interactions at the molecular level.
  • Databases aid in characterizing lectin specificity and identifying novel lectins.
  • Co-evolution drives the specific binding of microbes to host mucins.