The Physics of Cancer

Area of Science:

• Integrative biology
• Physical sciences in medicine
• Cancer research

Background:

• Cancer is often oversimplified as a genetic disease, neglecting its nature as a complex dynamic system.
• The physical environment significantly influences cancer cell evolution and behavior.
• Recognizing this complexity, the National Cancer Institute (NCI) initiated a novel program.

Purpose of the Study:

• To highlight successful integrations of physical sciences and cancer biology.
• To review key achievements from the first decade of the Physical Sciences-Oncology Network (PS-ON).
• To share lessons learned from this interdisciplinary initiative.

Main Methods:

• Systematic integration of physical sciences principles into cancer research.
• Multidisciplinary workshops and collaborative meetings.
• Analysis of key research areas and outcomes from the PS-ON program.

Main Results:

• Demonstrated successful integration of physical sciences into cancer biology and treatment.
• Identified critical areas where physical sciences have advanced cancer understanding.
• Documented valuable lessons from a decade of interdisciplinary collaboration.

Conclusions:

• The integration of physical sciences has significantly enriched cancer research beyond a purely genetic perspective.
• The Physical Sciences-Oncology Network (PS-ON) model provides a framework for future interdisciplinary cancer research.
• Continued focus on the physical microenvironment is crucial for advancing cancer treatment and biology.