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Association between retinal microvasculature and optic disc alterations in high myopia
Jiangnan He1,2,3,4, Qiuying Chen1,2,3,4, Yao Yin1,2,3,4
1Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye Hospital, Shanghai, China.
Eye (London, England)
|April 26, 2019
Summary
High myopia is associated with reduced retinal perfusion, including lower vessel density and larger foveal avascular zones. The tilted disc ratio is a key factor correlating with these changes in retinal blood flow.
Area of Science:
- Ophthalmology
- Retinal Imaging
- Vascular Biology
Background:
- High myopia is a significant risk factor for various ocular pathologies.
- Understanding the microvascular changes in high myopia is crucial for early detection and management.
Purpose of the Study:
- To investigate the characteristics of retinal perfusion in individuals with high myopia.
- To explore the association between retinal perfusion parameters and structural changes in high myopia.
Main Methods:
- Utilized optical coherence tomography angiography (OCTA) to measure peripapillary radial peripapillary capillary perfusion, foveal avascular zone, and parafoveal perfusion.
- Employed swept-source optical coherence tomography to assess tilted disc ratio and parapapillary atrophy.
- Analyzed data from 760 young healthy participants with myopic eyes.
Main Results:
- The high-myopia group showed significantly larger parapapillary atrophy and a lower tilted disc ratio compared to controls.
- Reduced radial peripapillary capillary vessel density and deep parafoveal vessel density were observed in the high-myopia group.
- An enlarged foveal avascular zone was also a significant finding in individuals with high myopia.
Conclusions:
- High myopia is characterized by diminished retinal perfusion, evidenced by reduced vessel density and an enlarged foveal avascular zone.
- The tilted disc ratio demonstrated a significant correlation with key retinal perfusion metrics, including radial peripapillary capillary density and deep parafoveal vessel density.
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