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Updated: Jan 25, 2026
18:48
Murine Renal Transplantation Procedure
Published on: July 10, 2009
30.6K
Accelerated Oxalosis Contributing to Delayed Graft Function after Renal Transplantation
Yvelynne P Kelly1, Astrid Weins2, Melissa Y Yeung1
1Department of Nephrology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA.
Case Reports in Transplantation
|April 26, 2019
Summary
Hyperoxaluria can cause kidney transplant failure. Early recognition and treatment with calcium citrate helped a patient recover from delayed graft function, highlighting its importance in transplant care.
Area of Science:
- Nephrology
- Transplantation Immunology
- Clinical Medicine
Background:
- Hyperoxaluria is a significant, often overlooked, cause of kidney allograft dysfunction and loss.
- Timely diagnosis of hyperoxaluria is crucial for implementing potentially effective treatments.
- Research is actively exploring new therapeutic strategies for hyperoxaluria.
Observation:
- A 59-year-old male recipient of a deceased donor kidney transplant experienced delayed graft function.
- Initial biopsy revealed acute tubular necrosis, peritubular capillaritis, interstitial nephritis, and oxalate crystals.
- Despite treatment for rejection, the patient remained dialysis-dependent.
Findings:
- A repeat biopsy showed persistent acute tubular necrosis with widespread oxalate crystals.
- Elevated plasma oxalate levels (19.3 μmol/L) confirmed hyperoxaluria.
- Initiation of calcium citrate therapy led to the patient becoming dialysis-independent within 3 weeks.
Implications:
- This case underscores accelerated oxalate nephropathy as an underappreciated factor in delayed graft function post-renal transplantation.
- Prompt diagnosis and management of hyperoxaluria can improve allograft outcomes.
- Current therapeutic measures for managing hyperoxaluria in transplant recipients warrant further discussion and research.
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