Related Experiment Video
Updated: Jan 25, 2026

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
Published on: January 18, 2018
Molecular signature of penumbra in acute ischemic stroke: a pilot transcriptomics study
Zurab Nadareishvili1,2, Devon Kelley1, Marie Luby1
1Section on Stroke Diagnostics and Therapeutics NINDS NIH Bethesda Maryland.
Abstract:
We aimed to characterize peripheral blood gene expression profile of penumbra defined as MRI perfusion-diffusion mismatch (PD MM) in peripheral blood of patients with acute ischemic stroke. We studied 23 patients. Perfusion-diffusion mismatch volume was observed to be associated and significantly correlated with the expression of 34 genes including those related to inflammation, SUMOylation, and coagulation; while lipopolysaccharide inhibition was identified to be a candidate upstream regulator of these processes (z-score -2.38, P = 0.04). Penumbral volume is correlated with a specific gene expression profile in the peripheral blood characterized by overlap of inflammatory and neuroprotective pathways that are regulated by lipopolysaccharide inhibition.
Related Concept Videos
Pilot and Numeric Relaying
Acute Pyelonephritis II: Diagnostic Studies and Management
Acute Coronary Syndrome III: Diagnostic Studies
Molecular Models
Acute Kidney Injury IV: Diagnostic Studies and Prevention
Molecular and Ionic Solids
Molecular Solids
Molecular crystalline solids, such as ice, sucrose (table sugar), and iodine, are solids that are composed of neutral molecules as their constituent units. These molecules are held together by weak intermolecular forces such as London dispersion forces, dipole-dipole interactions, or hydrogen bonds, which...

